Peptide Publications Archive
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Phosphorylation Mimics Hydroxylation
Raines Lab
Collagen stability depends on 4-hydroxyproline, a permanent modification. Now, researchers show that phosphorylation of threonine at the Yaa position of a collagen triple helix mimics …
Coiled-Coil Grafting
Wilson, Woolfson, and Itzhaki Groups
Protein–protein interactions are notoriously difficult to drug, but coiled-coil peptides offer a structured scaffold for presenting binding hot spots. Researchers grafted p53 hot-spot residues onto …
Folding the Sheet
Cai Lab
β-hairpins underpin protein recognition, amyloid assembly, and enzyme catalysis, yet engineering stable β-sheet mimics in small peptides remains stubbornly difficult. A new class of sulfonyl-modified …
Bifunctional Peptide Oxidation
Miller Lab
Axially chiral biaryl aldehydes are prized scaffolds in medicinal chemistry and asymmetric catalysis, yet enantioselective aerobic oxidations to access them have remained elusive. A new …
Backbone Heteroatom Shield
Del Valle Lab
Replacing backbone amide nitrogens with nitrogen or oxygen heteroatoms can slow protease degradation without sacrificing the folded structures peptides need to work. A tetra-N-aminated antimicrobial …
Linkers Shape Collagen
Merg Lab
Covalently tethered collagen-mimetic peptides fold into triple helices and assemble into nanosheets, but how does the linker connecting each strand to its scaffold influence stability? …
Coaxing New Vessels
Choi Lab
An AI-designed peptide mimics VEGF's receptor-activating power, accelerating wound closure in diabetic mice and raising hopes for a stable, tunable pro-angiogenic therapy
Engineering Disorder
Horne Group
Researchers in the Horne Group at the University of Pittsburgh, published in Biochemistry, set out to develop a systematic method for manipulating the unfolded …
Inside-Out Peptides
Gladysz Group
Macrobicyclic peptides can flip inside-out via homeomorphic isomerization, creating distinct structures with different biological properties.
Frankenproteins Block Myc
Shin Lab
The proto-oncogene MYC is dysregulated in more than 70% of human cancers and drives some of the most aggressive subtypes of breast cancer. Triple-negative breast …
Frankenprotein Precision
Shin Lab
Researchers in the Shin Group at Chapman University, published in ACS Synthetic Biology, drew inspiration from an unusual source: the homeodomain-leucine zipper transcription factor …
Budding Immunity
Mayo Group
Immune cells naturally release extracellular vesicles studded with peptide-MHC complexes that can orchestrate immune responses, either directly stimulating T cells or transferring their cargo to …
Mapping Membrane Activity
Hennig & Nau Labs
Cell-penetrating peptides and antimicrobial peptides both interact with lipid membranes, but with fundamentally different outcomes. Cell-penetrating peptides slip through membranes while leaving them largely intact, …
Targeted Evolution
Jumi Shin Lab
Rational protein design can create remarkable molecules, but it explores only a sliver of sequence space. The Shin group at the University of Toronto has …
Computational Peptide Design
Guo Group
Xanthine oxidase catalyzes the final steps of purine catabolism, converting hypoxanthine and xanthine to uric acid. Dysregulation of this enzyme leads to excessive uric acid …
Binders by Design
Pomplun Lab
Discovering high-affinity ligands directly from protein structures has long tantalized drug discovery scientists. Virtual screening can explore billions of small molecules computationally, yet hit rates …
β-Hairpin Oligomers
Nowick Lab
Researchers in the Nowick Group at the University of California Irvine, reveal how a designed β-hairpin peptide derived from amyloid-β, Aβ, crosses the boundary from …
TCR Peptide Design
Nourmohammad Lab
In work published in PNAS, Visani and colleagues from the University of Washington, introduce a structure-aware machine learning approach that forecasts TCR–peptide–MHC interactions and …
Docking Bias
Keating Lab
Deep-learning structure predictors now place many peptides correctly onto their protein partners, and this recent work from Lindsey Guan and Amy Keating at the Massachusetts …
Helical Hydrazides
Gellman Lab
Seeking to understand the relative kinetic benefits of reactive unit connection and preorganization, researchers from the Gellman Lab at the University of Wisconsin–Madison investigated α/β-peptide …
Azapeptoid Collagen
Del Valle Lab
Collagen’s mechanical grace comes from a deceptively simple code: repeating Gly-Xaa-Yaa triplets that assemble into three left-handed PPII chains winding into a right-handed triple helix. …
Stapled Sheets
Del Valle Lab
The stabilization of β-sheet structures has long been a challenge in peptide design, despite their central role in mediating protein–protein interactions, PPIs. While side-chain …
Conformational Equilibrium
Serianni Lab
The conformational behavior of alanine dipeptide, Ac-L-Ala-NHMe, 1, has long made it a model compound in molecular simulation studies. However, despite numerous …
Proline Scanning
Wu Lab
Disulfide-rich peptides, DRPs, are renowned for their stability and therapeutic promise, yet their natural structures offer limited flexibility for evolution or functional adaptation. In an …